The first issue to be considered with regard to the nanomaterials being utilized in medicine centers on their safety.The functionality of nanocarriers in real-life environments explains the enthusiasm for their use.
It ishoped that nanoparticles (NPs) can be used to overcome this problem, by actingas vehicles to transport nucleic acids through the body for specific delivery intodiseased cells.
The results demonstrate that size and surface charge of Au NP interact in an interrelated fashion to modulate nanoparticle internalization by cells, providing an engineering strategy for designing nanomaterials for drug delivery applications.
Later, I engineered an environmentally responsive nanoparticle-protein interface for real time hydrogen peroxide (H) sensing and monitoring of cellular oxidative stress.
The responsiveness of this system demonstrates the utility of co-engineering synthetic-biological hybrid nanomaterials.
Moreover, I developed gold nanoparticle-stabilized nanocapsules (NPSCs) for gene delivery to enhance cancer therapy and immunomodulation efficiency.